Human Traumatic Brain Injury Alters Plasma microRNA Levels
نویسندگان
چکیده
منابع مشابه
Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats.
Therapeutic hypothermia promotes protection after traumatic brain injury (TBI). The mechanisms underlying hypothermic protection are multifactorial and may include the modulation of microRNA (miRNA) expression after trauma. We utilized microarrays to examine the effects of posttraumatic hypothermia on the expression of 388 rat miRNAs. Animals were subjected to sham or moderate fluid percussion ...
متن کاملTraumatic Brain Injury Alters Methionine Metabolism: Implications for Pathophysiology
Methionine is an essential proteinogenic amino acid that is obtained from the diet. In addition to its requirement for protein biosynthesis, methionine is metabolized to generate metabolites that play key roles in a number of cellular functions. Metabolism of methionine via the transmethylation pathway generates S-adenosylmethionine (SAM) that serves as the principal methyl (-CH3) donor for DNA...
متن کاملO 27: Traumatic Brain Injury and Inflammation
Traumatic brain injury (TBI) is a significant public health concern in our country, because of placing in top three most common causes of death and substantial direct and indirect costs to society. The incidence of TBI in our country is 1.7 times of international incidence. Traumatic brain injury induced by primary and secondary mechanisms that give rise to death and neurologic morbidity in pat...
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ژورنال
عنوان ژورنال: Journal of Neurotrauma
سال: 2010
ISSN: 0897-7151,1557-9042
DOI: 10.1089/neu.2010.1481